Dopamine Receptor
Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4receptors are members of the D2-like family.
Dopamine Receptor Isoform Specific Products
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Dopamine Receptor Inhibitors
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Dopamine Receptor Agonists
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Dopamine Receptor Antagonists
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Dopamine Receptor Chemical
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Dopamine Receptor MDM2 Inhibitor
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Dopamine Receptor Controls
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Dopamine Receptor Ligands
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Dopamine Receptor Related Products (1078)
Related Products (1078)
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Antibodies (7)
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Related Compound Screening Libraries (1)
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Dopamine Receptor Isoform Comparison
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Pipamperone-d10 dihydrochloride
0 ImagesCat. No.: HY-100703SSynonyms: Floropipamide-d10 dihydrochloride; McN-JR 3345-d10 dihydrochloride; R 3345-d10 dihydrochloridePipamperone-d10 (Floropipamide-d10) dihydrochloride is a deuterated Pipamperone dihydrochloride (HY-100703A). Pipamperone dihydrochloride (Floropipamide dihydrochloride) is a butyrophenone derivative and high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0). Pipamperone dihydrochloride is also a low-affinity antagonist of D2 receptor (pKi=6.7). Pipamperone dihydrochloride affects neurotransmitter functions and exerts antipsychotic activity. Pipamperone dihydrochloride is used in the research of mental disorders such as autism-related behavioral disorders and Alzheimer's disease.
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Seproxetine hydrochloride
0 ImagesCat. No.: HY-124357CAS No.: 127685-30-7Synonyms: S-Norfluoxetine hydrochloride; LY 215229 hydrochlorideSeproxetine (S-Norfluoxetine) hydrochloride is a selective serotonin reuptake inhibitor (SSRI) that enhances serotonin levels in the brain by specifically inhibiting the serotonin uptake carrier. Seproxetine hydrochloride exhibits strong charge transfer interactions with π-electron acceptors, forming stable complexes that enhance its binding affinity to multiple receptors, including serotonin and dopamine receptors. Seproxetine hydrochloride demonstrates improved biological activity when interacting with charge transfer complexes, leading to increased stability and efficacy in therapeutic applications.
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Piribedil-d4
0 ImagesCat. No.: HY-12707S1Piribedil-d4 is the deuterium labeled Piribedil (HY-12707). Piribedil is a potent and orally active dopamine D2 and dopamine D3 agonist. Piribedil is also a α2-adrenoceptors antagonist. Piribedil can inhibit MLL1 methyltransferase activity (EC50: 0.18 μM). Piribedil has the potential for the research of parkinson's disease, circulatory disorders, cancers.
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OPC-4392
0 ImagesCat. No.: HY-106781CAS No.: 111073-34-8OPC-4392 is a orally active presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist. OPC 4392 reverses the Reserpine (HY-N0480)-induced dopamine accumulation, inhibits Apomorphine (HY-12723)-induced stereotypic and climbing behaviors in mouse models. OPC-4392 can be used as antipsychotic agent.
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Nor-SCH-12679 maleate
0 ImagesCat. No.: HY-48817CAS No.: 20049-44-9Nor-SCH-12679 (maleate) is a compound mentioned in the study of the effects of peppermint oil components on mouse activity. As a dopamine antagonist, it can weaken the promoting effect of peppermint oil components on mouse activity.
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JNJ-37822681
0 ImagesCat. No.: HY-111066CAS No.: 935776-74-2JNJ-37822681 is a fast dissociating D2 antagonist with activity in inhibiting schizophrenia. JNJ-37822681 has high specificity for D2 receptors and is effective in animal models, inducing increased levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex, and exhibiting antidepressant activity in the mouse tail suspension test, while having a good brain distribution and lower prolactin release.
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Promazine
0 ImagesPromazine (Romtiazin) is an antipsychotic and a dopamine receptor D2 antagonist. Promazine inhibits dopaminergic neurotransmission.
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Ropinirole-d14
0 ImagesCat. No.: HY-B0623SCAS No.: 1132746-05-4Synonyms: SKF 101468-d14Ropinirole-d14 is the deuterium labeled Ropinirole.
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Bromperidol (Standard)
0 ImagesCat. No.: HY-B0901RCAS No.: 10457-90-6Synonyms: R-11333 (Standard)Bromperidol (Standard) is the analytical standard of Bromperidol. This product is intended for research and analytical applications. Bromperidol (R-11333) possesses antipsychotic activity, with a high affinity for central dopamine receptors D2. Bromperidol can kill Mycobacteria in a synergistic manner with Spectinomycin.
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Raclopride tartrate
0 ImagesCat. No.: HY-108976CAS No.: 98185-20-7Raclopride tartrate is a selective dopamine D2/D3 receptor antagonist with potential antipsychotic effects. Raclopride tartrate binds to D2 and D3 receptors with Kis of 1.8 nM and 3.5 nM, respectively.
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Olanzapine-d8
0 ImagesCat. No.: HY-14541S2CAS No.: 1093380-13-2Synonyms: LY170053-d8Olanzapine-d8 is a deuterated labeled Olanzapine. Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic.
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BMS-570520
0 ImagesCat. No.: HY-182735CAS No.: 388101-58-4BMS-570520 is an orally bioavailable CCR3 antagonist with an IC50 of 1.9 nM against hCCR3 and an IC50 of 1300 nM against hCYP2D6. BMS-570520 inhibits CYP2D6, but shows low activity against off-target G protein-coupled receptors, biogenic amine transporters, and the hERG potassium channel. BMS-570520 regulates chemotaxis, calcium mobilization, and anti-inflammatory pathways. BMS-570520 can be used in research related to asthma, allergic rhinitis, and contact dermatitis.
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Fezolamine
0 ImagesCat. No.: HY-106079CAS No.: 80410-36-2Fezolamine is an orally active non-tricyclic compound , and shows antidepressant activity.
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Dopamine D3 receptor ligand-4
0 ImagesCat. No.: HY-115968CAS No.: 2376333-77-4Dopamine D3 receptor ligand-4 (compound 6) is a potent and selective dopamine D3 receptor ligand, with a Ki of 0.5 nM. Dopamine D3 receptor ligand-4 shows high level of selectivity for D3 over D2 (Ki=7.43 nM).
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S 33138
0 ImagesCat. No.: HY-14555CAS No.: 245514-32-3S33138 is a D3 receptor antagonist. S33138 inhibits addiction in animal models of addiction. S33138 reduces cognitive impairment in rodent and primate models of schizophrenia and Parkinson's disease. S33138 can be used in research on neurological disorders such as schizophrenia and Parkinson's disease.
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Risperidone (Standard)
0 ImagesSynonyms: R 64 766 (Standard)Risperidone (Standard) is the analytical standard of Risperidone. This product is intended for research and analytical applications. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.
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Tipepidine citrate
0 ImagesCat. No.: HY-B2185CAS No.: 14698-07-8Tipepidine citrate is a non-narcotic antitussive agent. Tipepidine citrate reversibly inhibits dopamine D2 receptor-mediated GIRK current (IDA(GIRK)), thereby activating VTA dopamine neurons, with an IC50 of 7.0 μM for IDA(GIRK). Tipepidine activates AMPK. Tipepidine citrate has antidepressant-like effects. Tipepidine citrate enhances the analgesic effect of Carbamazepine (HY-B0246). Tipepidine citrate improves adipose tissue fibrosis and glucose intolerance in high-fat diet-induced obese mice.
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Mafoprazine (Standard)
0 ImagesCat. No.: HY-126635RCAS No.: 80428-29-1Mafoprazine (Standard) is the analytical standard of Mafoprazine. This product is intended for research and analytical applications. Mafoprazine is a phenylpiperazine derivative with variable affinities for neuronal receptors. It may exert its antipsychotic effects primarily through D2 receptor blockade and α-adrenergic activity, and may increase the activity of dopamine metabolites.
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UNC9815
0 ImagesCat. No.: HY-179240UNC9815 is a D1 dopamine receptor (D1R) orthosteric allosteric modulator (PAM). UNC9815 can dose-dependently enhance the functional efficacy of dopamine in β-inhibitory protein recruitment experiments and cAMP accumulation experiments. When used in combination with other PAMs, UNC9815 exhibits a significant synergistic enhancement effect. UNC9815 can be used to study neurological and psychiatric diseases such as Parkinson's disease and schizophrenia.
